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Galleriamellonella are Resistant to Pneumocystismurina Infection
Authors:Beth Burgwyn Fuchs  Lisa R. Bishop  Joseph A. Kovacs  Eleftherios Mylonakis
Affiliation:(1) Division of Infectious Diseases, Massachusetts General Hospital, Gray-Jackson 504, 55 Fruit Street, Boston, MA 02114, USA;(2) Critical Care Medicine Department, National Institutes of Health Clinical Center, Bethesda, MD, USA
Abstract:Studying Pneumocystis has proven to be a challenge from the perspective of propagating a significant amount of the pathogen in a facile manner. The study of several fungal pathogens has been aided by the use of invertebrate model hosts. Our efforts to infect the invertebrate larvae Galleria mellonella with Pneumocystis proved futile since P. murina neither caused disease nor was able to proliferate within G. mellonella. It did, however, show that the pathogen could be rapidly cleared from the host.
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