Regulation of traffic and organelle architecture of the ER-Golgi interface by signal transduction |
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Authors: | Kerstin D Tillmann Valentina Millarte Hesso Farhan |
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Institution: | 1. Biotechnology Institute Thurgau, Unterseestrasse 47, 8280, Kreuzlingen, Switzerland 2. Department of Biology, University of Konstanz, Universit?tsstrasse 10, 78464, Constance, Germany
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Abstract: | The components that control trafficking between organelles of the secretory pathway as well as their architecture were uncovered to a reasonable extent in the past decades. However, only recently did we begin to explore the regulation of the secretory pathway by cellular signaling. In the current review, we focus on trafficking between the endoplasmic reticulum and the Golgi apparatus. We highlight recent advances that have been made toward a better understanding of how the secretory pathway is regulated by signaling and discuss how this knowledge is important to obtain an integrative view of secretion in the context of other homeostatic processes such as growth and proliferation. |
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