Possibility of reversing the action of the membranotropic antibiotic, gramicidin S, on bacteria |
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Authors: | V G Bulgakov G N Vostroknutova P N Korolev D N Ostrovski? A N Polin |
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Abstract: | The study on the possibility of eliminating gramicidin S from the bacterial cells which had adsorbed it showed that a part of the labeled antibiotic bound by the bacteria may be washed out with buffer or salines. When the cells which had adsorbed gramicidin S were treated with lecithin emulsion, a significant part of the bound antibiotic was transferred to the lecithin liposomes. This turned the gramicidin S effect to the cells: significant but not complete reduction of the membrane barrier properties and dehydrogenase reactivation. Elimination of gramicidin S also reduced the colony forming capacity in a part of the cells. |
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