Catalytic site-selective synthesis and evaluation of a series of erythromycin analogs |
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Authors: | Lewis Chad A Merkel Janie Miller Scott J |
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Institution: | Department of Chemistry, Yale University, 225 Prospect Street, New Haven, CT 06520-8107, USA. |
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Abstract: | The generation of a series of analogs of erythromycin A (EryA, 2) is described. In this study, we compared two peptide-based catalysts-one originally identified from a catalyst screen (5) and its enantiomer (ent-5)-for the selective functionalization of EryA. The semi-synthetic analogs were subjected to MIC evaluation with two bacterial strains and compared to unfunctionalized EryA. |
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