Th细胞亚群在自身免疫病的发病及治疗中作用的实验研究进展

本文回顾了Ｔｈ细胞亚群的功能、交互调节、影响其分化的因素以及Ｔｈ细胞亚群在自身免疫病发病中的可能作用；概括了通过调节Ｔｈ细胞亚群来治疗自身免疫病的方法，包括：上调ＣＤ１ｄ治疗、给予相关细胞因子治疗、佐剂治疗、用抗细胞因子、细胞因子受体、ＣＤ４０配体和Ｂ７分子的单克隆抗体治疗以及ＣＴＬＡ和ＣＴＬＡＩｇ治疗。这些方法为自身免疫病的治疗提供了新的思路。

Advances in the Experimental Study on the Role of Helper T Cell Subsets in the Pathogenesis and the Treatment of Autoimmune Diseases

In this paper the functions of helper T(Th) cell subsets, their cross regulation and agents affected their differentiation, as well as the role of Th subsets in the possible pathogenesis of autoimmune diseases were reviewed. Furthermore, a lot of opinions on autoimmune diseases therapy through restoration of Th subsets balance were mentioned. The available measurements to be used include up regulation of CD1d, administration of relative cytokines,administration of Freund adjuvant, administration of monoclonal antibodies against cytokines,cytokine receptors, CD40 ligand or B7 molecule, as well as CTLA or CTLAIg pathway and so on.