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Reactivity of fluorodinitrobenzene with intact human leucocytes: Examination of sites of action and the molecular entities involved in interaction |
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| Authors: | S. S. Joshi V. S. Basrur M. B. Sahasrabudhe |
| Affiliation: | (1) Cancer Research Institute, Tata Memorial Centre, Parel, 400 012 Bombay;(2) Present address: Indiana University School of Medicine, 46408 Gary, Indiana, USA;(3) Present address: 41, Saras Baug, Sion-Trombay Road, Deonar, 400 088 Bombay |
| Abstract: | The epsilon amino groups of lysine and to a lesser extent amino groups on phosphotidyl ethanolamine and phosphotidyl serine situated on cell membranes of normal human leucocytes have been identified as the sites of dinitrophenylation.In situ conversion of 10,000 hydrophylic amino sites into hydrophobic sites on cell surfaces causes conformational changes in cell membranes with exposures of leukaemic cell-specific neo-antigens on tagged cell surfaces. |
| Keywords: | Dinitrophenylated leucocytes leukaemia-associated antigenicity hydrophylic-hydrophobic interconversions dinitrophenylated-epsilon lysine dinitrophenylated phosphatidyl ethanolamine dinitrophenylated-phosphatidyl serine |
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