Evolutionary dynamics of U12-type spliceosomal introns |
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| Authors: | Chiao-Feng Lin Stephen M Mount Artur Jarmołowski Wojciech Makałowski |
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| Institution: | 1.Institute of Bioinformatics,University of Muenster,Muenster,Germany;2.1413 Blockley Hall, Center for Bioinformatics, 423 Guardian Dr,University of Pennsylvania,Philadelphia,USA;3.Department of Cell Biology and Molecular Genetics,University of Maryland,Maryland,USA;4.Center for Bioinformatics and Computational Biology,University of Maryland,Maryland,USA;5.Department of Gene Expression, Institute of Molecular Biology and Biotechnology,Adam Mickiewicz University,Pozna?,Poland |
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| Abstract: | Background Many multicellular eukaryotes have two types of spliceosomes for the removal of introns from messenger RNA precursors. The
major (U2) spliceosome processes the vast majority of introns, referred to as U2-type introns, while the minor (U12) spliceosome
removes a small fraction (less than 0.5%) of introns, referred to as U12-type introns. U12-type introns have distinct sequence
elements and usually occur together in genes with U2-type introns. A phylogenetic distribution of U12-type introns shows that
the minor splicing pathway appeared very early in eukaryotic evolution and has been lost repeatedly. |
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