Peptaibol Derived Helix‐Kink Motif Facilitates Channel Forming of the Artificial α-Aminoisobutyric Acid Rich Helices |
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Authors: | Junichi Taira Mitsukuni Shibue Satoshi Osada Hiroaki Kodama |
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Institution: | (1) Department of Chemistry, Faculty of Science and Engineering, Saga University, Saga 840-8502, Japan;(2) Present address: Department of Chemistry, Kurume University School of Medicine, Kurume 830-0011, Japan; |
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Abstract: | Characteristic motifs have been identified in natural channel forming peptides though critical roles of such motifs are not
well understood. In this paper, the helix‐kink motif found in peptaibols was embedded into the α-aminoisobutyric acid (Aib)
rich template to explore its roles in peptide structure and ion channel functions. According to circular dichroism studies
and single channel measurements, the motif reduced helical contents of peptide whereas ion channel forming was facilitated
and conductance value was increased. |
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Keywords: | |
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