Effect of fenoterol, ipratropium bromide and their combination--Berodual--on pulmonary ventilation in patients with asthma

The study aimed at evaluating FVC, FEV1, and FMF25-75% following and inhalation of fenoterol, ipratropium bromide and Berodual in 10 patients with the bronchial asthma. Berodual may be inhaled directly from the metered dose inhaler or with added tube spacer. Spirometry was performed after a single deep inspiration of each drug in the consecutive days, and after 5, 15, 30 and 60 minutes as well as 2, 3, 4, and 5 hours following the inhalation. The differences at each time point were compared with baseline values and expressed as percentage of the increase. The obtained results were analysed statistically. It was shown that bronchodilatory action of Berodual, being both beta 2-agonist and anticholinergic agent, is the most pronounced. The highest values of the measured spirometric parameters followed Berodual inhalation with the aid of tube spacer but the differences compared with Berodual applied with the metered dose inhaler were not statistically significant.