Comparative evaluation of D-glucosyl thiouronium, glucosylthio heterocycles, Daonil, and insulin as inhibitors for hepatic glycosidases |
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| Authors: | El din Awad Olfat M Attia Wafaa E El Ashry El Sayed H |
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| Institution: | Department of Biochemistry, Faculty of Science, Alexandria University, Alexandria 21321, Egypt. |
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| Abstract: | Comparison of the in vivo and in vitro effects of S-(2,3,4,6-tetra-O-acetyl-beta-D-glucopyranosyl)thiuronium bromide (1), 2-(2,3,4,6-tetra-O-acetyl-beta-D-glucopyranosylthio-1,3,4-thiadiazolin-5-thione (2), and 2-(2,3,4,6-tetra-O-acetyl-beta-D-glucopyranosylthio)-1,3-benzoxazole (3), as well as the antidiabetics Daonil and insulin on glycosidase enzymes has been investigated. Compound 1 inhibited both alpha- and beta-glucosidases, but the inhibition was more potent with the beta-enzyme. Compound 2 was found to be a weaker inhibitor of these enzymes, while compound 3 showed a slight apparent activation. |
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| Keywords: | α-Glucosidase β-Glucosidase Glucopyranosylthio Thiouronium Thiadiazolinthione Benzoxazole |
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