Asynchronous replication of constitutive heterochromatin on X chromosomes in female Mus dunni |
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Authors: | S Sen T Sharma |
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Institution: | (1) Cytogenetics Laboratory, Department of Zoology, Banaras Hindu University, 221005 Varanasi, India |
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Abstract: | Euchromatin DNA of one X chromosome in mammalian females, which becomes facultatively heterochromatinized, is known to replicate asynchronously late in S phase compared to its active homologue. In the females of a pygmy mouse species Mus dunni, which has prominent segment of constitutive heterochromatin as the short arm of its submetacentric X chromosome, we have observed asynchronous replication of c-heterochromatin arm as well, predominant number of cells showing the segment associated with the facultatively heterochromatic X to be terminating later. The preferential later termination of replication of the c-heterochromatic arm on the lyonized X appears to be due to the influence of facultative heterochromatin on the adjacent constitutive heterochromatin. |
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