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A polymorphic locus on the long arm of chromosome 20 defined by two probes from a single cosmid |
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| Authors: | M Litt R Sheehy G A Bruns R E Magenis |
| Institution: | (1) Department of Medical Genetics, Oregon Health Sciences University, 97201 Portland, OR, USA;(2) Department of Biochemistry, Oregon Health Sciences University, 97201 Portland, OR, USA;(3) Crippled Children's Division, Oregon Health Sciences University, 97201 Portland, OR, USA;(4) Genetics Division and Mental Retardation Research Center, Children's Hospital, 02115 Boston, MA, USA |
| Abstract: | Summary Two probes from the random human cosmid c1-37 detect restriction fragment length polymorphisms in humans. The loci revealed by these probes are in linkage equilibrium and constitute a compound polymorphic locus with a polymorphism information content of 0.54. A somatic cell hybrid panel has been used to map the probes to chromosome 20; in situ hybridization studies confirm this localization and indicate that the locus is on 20q13. This is the first polymorphic locus to be assigned to the long arm of chromosome 20. |
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