Apoptotic effects and glucose-6-phosphate dehydrogenase responses in liver and gill tissues of rainbow trout treated with chlorpyrifos |
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| Authors: | Ahmet Topal Muhammed Atamanalp Ertan Oruç Muammer Kırıcı Esat Mahmut Kocaman |
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| Affiliation: | 1. Department of Basic Sciences, Faculty of Fisheries, Ataturk University, TR-25240 Erzurum, Turkey;2. Department of Aquaculture, Faculty of Fisheries, Ataturk University, TR-25240 Erzurum, Turkey;3. Department of Pathology, Faculty of Veterinary, Ataturk University, TR-25240 Erzurum, Turkey;4. Department of Aquaculture, Faculty of Agriculture, Bingöl University, TR-12000 Bingöl, Turkey |
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| Abstract: | We investigated apoptotic effects and changes in glucose-6-phosphate dehydrogenase (G6PD) enzyme activity in liver and gill tissues of fish exposed to chlorpyrifos. Three different chlorpyrifos doses (2.25, 4.5 and 6.75 μg/L) were administrated to rainbow trout at different time intervals (24, 48, 72 and 96 h). Acute exposure to chlorpyrifos showed time dependent decrease in G6PD enzyme activity at all concentrations (p < 0.05). Immunohistochemical results showed that chlorpyrifos caused mucous cell loss in gill tissue and apoptosis via caspase-3 activation in fish. The present study suggested that chlorpyrifos inhibits G6PD enzyme and causes mucous cell loss in gill and apoptosis in gill and liver tissues. |
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| Keywords: | Chlorpyrifos Gill Liver Immunohistochemistry Apoptosis Glucose-6-phosphate dehydrogenase |
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