Correlation between the toxicity of platinum drugs to L1210 leukaemia cells and their mutagenic properties. |
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| Authors: | P Lecointe J P Macquet J L Butour |
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| Institution: | Laboratoire de Pharmacologie et de Toxicologie fondamentales du CNRS 205, route de Narbonne, 31078 Toulouse Cedex, France |
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| Abstract: | There is a good correlation between the growth inhibitory properties of a series of Pt(II) derivatives on cultured L1210 mouse leukaemia cells and their efficiency of reversion to his+ of S. typhimurium TA100, or with their forward mutagenic effects on prophage λ. Reactivity towards DNA may thus explain the antitumor properties of these drugs. |
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