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Two new protease-inhibiting glycosphingolipids from Buddleja crispa |
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| Authors: | Ahmad Ijaz Anis Itrat Fatima Itrat Malik Abdul Khan Shafiullah Afza Nighat Tareen Rasool Bakhsh Lodhi Muhammad Arif Choudhary M Iqbal |
| Affiliation: | H.E.J. Research Institute of Chemistry, University of Karachi, Karachi-75270, Pakistan. |
| Abstract: | Crispins A (1) and B (2), two new glycosphingolipids, were isolated from the whole plant Buddleja crispa, along with three known compounds: alpha-amyrin, linoleic acid, and stigmasterol. Their structures were elucidated by chemical and spectroscopic techniques. Both 1 and 2 showed significant inhibitory activity against alpha-chymotrypsin in a concentration-dependent manner. |
| Keywords: | Buddleja crispa Glycosphingolipids Chymotrypsin inhibition Protease inhibition Inhibitors Crispins A and B |
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