| 天然甾体皂甙化合物的抗肿瘤活性 |
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| 引用本文： | 李忌,巨勇.天然甾体皂甙化合物的抗肿瘤活性[J].天然产物研究与开发,1999,11(1):14-17. |
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| 作者姓名： | 李忌 巨勇 |
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| 作者单位： | 华西医科大学基础医学院重组DNA研究室!成都610041(李忌，陈俊杰)，应用有机化学国家重点实验室(巨勇，贾忠建)，兰州大学生物系!兰州730000(郑荣梁) |
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| 摘 要： | 采用MTT法,以长春新碱(VCR)为阳性对照,研究了6种从菝葜属植物中分离提取的天然甾体皂甙化合物对肝癌SMMC-7721、人宫颈癌HeLa和胃腺癌MGc80-3细胞生长的抑制作用.结果显示;6种甾体皂甙抗肿瘤活性与其化学结构密切相关,对三种癌细胞的抑瘤作用强度相同,抑癌活性的顺序为:薯蓣皂甙>VCR>SQD_4>SQD_3>M_1>SQD_1,甲基原薯蓣皂甙.甾体骨架的差异性是决定这类化合物抗肿瘤活性的主要因素.
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| 关 键 词： | 甾体皂甙化合物 菝葜 肝癌SMMC-7721 人宫颈癌HeLa 胃腺癌MGc80-3 |
ANTITUMOUR EFFECTS OF STEROIDAL SAPONINS |
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| Li Ji,Chen Junjie,Ju Yong,Jia Zhongjian,Zheng Rongliang.ANTITUMOUR EFFECTS OF STEROIDAL SAPONINS[J].Natural Product Research and Development,1999,11(1):14-17. |
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| Authors: | Li Ji Chen Junjie Ju Yong Jia Zhongjian Zheng Rongliang |
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| Abstract: | The antitumour activities of 6 natural steroidal saponins extracted from Smilax on hepatoma SMMC-7721 cell,human cervicarcinoma HeLa cell and human gastric adenocarcinoma. MGc80-3 cell vs well known antitumour drug, vincristine (VCR),were studied using the MTT colorimetric assay. The results showed that the antitumour effects of 6 steroidal saponins were related both to their chemical structures and to tumour cell lines susceptibities to tested compounds. The antitumour effects ranked as dioscin>VCR>DQD4>SQD3>M1>SQD1,methyl protodioscin. The steroidal structure of these steroidal saponins was the decisive factor for their antitumour activities. |
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| Keywords: | Steroidal saponins Smilax Hepatoma SMMC-7721 Human cervicarcinoma HeLa Human gastric adenocarcinoma MGc80-3 |
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