Differential effects of short and long term lithium on tryptophan uptake and serotonergic function in cat brain |
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Authors: | A C Swann G R Heninger R H Roth J W Maas |
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Institution: | 1. Department of Psychiatry, Yale University School of Medicine, 333 Cedar Street, New Haven, Connecticut 06510, USA;2. Connecticut Mental Health Center, USA |
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Abstract: | The effcts of short and long term lithium treatment on tryptophan uptake and on tissue levels of the serotonin metabolite 5-hydroxyindoleacetic acid (5-HIAA) were studied in twelve brain regions of the cat. Tryptophan uptake and 5-HIAA were significantly correlated in control cats. Short term treatment caused parallel increases or decreases in tryptophan uptake and 5-HIAA. Long term treatment consistently increased tryptophan uptake without corresponding changes in 5-HIAA. Relatively low cumulative doses of lithium may reduce the degree to which tryptophan uptake is a limiting factor in the the regulation of serotonin synthesis. |
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