| 非小细胞肺癌中HMGA2的表达与细胞增殖的关系 |
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| 引用本文： | 兰芬,熊盛道,熊维宁,杨硕,史雪梅,徐国鹏,陆晓霞,胡琼洁.非小细胞肺癌中HMGA2的表达与细胞增殖的关系[J].中国组织化学与细胞化学杂志,2008,17(5):416-420. |
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| 作者姓名： | 兰芬 熊盛道 熊维宁 杨硕 史雪梅 徐国鹏 陆晓霞 胡琼洁 |
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| 作者单位： | 华中科技大学同济医学院附属同济医院呼吸内科,武汉,430030 |
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| 摘 要： | 目的探讨High mobility group A2 protein（HMGA2）的表达对非小细胞肺癌生长、转移的影响，与临床病理参数和细胞增殖的关系。方法应用免疫组化法检测38例非小细胞肺癌组织（23例鳞癌，15例腺癌）及癌旁的正常肺组织标本中HMGA2和Ki-67的表达。结果HMGA2和Ki-67在癌旁的正常肺组织中均不表达，而在肺癌组织中的表达阳性率分别为39．47％、44．74％，二者在肺癌组和癌旁的正常肺组织组之间差异有显著性（P〈0．05）。HMGA2的表达在伴淋巴结转移的肺癌组织明显高于不伴有淋巴结转移的肺癌组织（P〈0．05），而与其他临床病理参数包括肿瘤的分化程度、肿瘤大小和TNM分期以及细胞增殖指标Ki-67之间没有相关性。结论本研究显示HMGA2在非小细胞肺癌组织中异常表达，可能与肺癌的发生和进展有关。
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| 关 键 词： | 高迁移率蛋白A族2 非小细胞肺癌 细胞增殖 免疫组织化学 |
EXPRESSION OF HMGA2 AND ITS RELATIONSHIP WITH CELL PROLIFERATION IN NON-SMALL CELL LUNG CANCER |
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| Lan Fen,Xiong Shengdao,Xiong Weining,Yang Shuo,Shi Xuemei,Xu Guopeng,Lu Xiaoxia,Hu Qiongjie.EXPRESSION OF HMGA2 AND ITS RELATIONSHIP WITH CELL PROLIFERATION IN NON-SMALL CELL LUNG CANCER[J].Chinese Journal of Histochemistry and Cytochemistry,2008,17(5):416-420. |
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| Authors: | Lan Fen Xiong Shengdao Xiong Weining Yang Shuo Shi Xuemei Xu Guopeng Lu Xiaoxia Hu Qiongjie |
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| Institution: | Lan Fen,Xiong Shengdao,Xiong Weining,Yang Shuo,Shi Xuemei,Xu Guopeng,Lu Xiaoxia,Hu Qiongjie(Department of Respiratory Medicine,Tongji Hospital,Tongji Medical College,Huazhong University of Science , Technology,Wuhan 430030,China) |
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| Abstract: | Objective To evaluate the effects of the High mobility group A 2 protein(HMGA2) expression in non-small cell lung cancer(NSCLC) on tumor growth and metastasis,and to explore the relationship between HMGA2 and clinicopathologic factors and cell proliferation index.Methods Inmmunohistochemistry was applied to detect the expression of HMGA2 and Ki-67 proteins in 38 cases of NSCLC(23 cases of lung squamous cell cancer,15 cases of lung adenocarcinoma) and tumor-surrounding normal lung tissues.Results HMGA2 and K... |
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| Keywords: | High mobility group A 2 protein Non-small cell lung cancer Cell proliferation Inmmunohistochemistry |
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