Enhanced fibronectin-mediated cell adhesion of human osteoblast by fibroblast growth factor, FGF-2 |
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| Authors: | Jun-Hyeog Jang Young Ku Chong-Pyoung Chung Seong-Joo Heo |
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| Affiliation: | (1) Intellectual Biointerface Engineering Center, Seoul National University College of Dentistry, Seoul, 110-768, Korea |
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| Abstract: | Using specific recombinant human fibronectin peptide (hFNIII9-10) that contains the binding site for integrin, we found that the fibroblast growth factor, FGF-2, enhances fibronectin-mediated adhesion in human osteoblast-like MG63 cells. The mechanism of the synergistic adhesion was due to the activation of extracellular-regulated kinase (ERK)-type MAPK upon interaction of integrin to hFNIII9-10 and its downstream activation of signaling pathways. |
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| Keywords: | cell adhesion extracellular matrix FGF-2 fibronectin signal transduction |
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