Tissue-specific distribution of uncoupling proteins in normal rats and rats with high-fat-diet-induced obesity |
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| Authors: | Chun-Mei Zhang Ying Gu Da-ni Qing Jin-gai Zhu Chun Zhu Min Zhang Xi-Rong Guo |
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| Institution: | (1) Department of Pediatrics, Nanjing Maternal and Child Health Hospital of Nanjing Medical University, Nanjing, China;(2) Institute of Pediatrics, Nanjing Medical University, Nanjing, China;(3) School of Pharmacy, Nanjing Medical University, Nanjing, China; |
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| Abstract: | Uncoupling proteins (UCPs) are a proton transporter family located in the mitochondrial inner membrane. Thus far, five molecules
(UCP1–UCP5) have been identified as members of the UCP family. Recently, UCPs have attracted considerable interest in research
on energy metabolism and obesity. However, to date, no study has focused on a comprehensive and systematic evaluation of the
tissue-specific distribution of UCPs in obese individuals. Our study presents evidence of differential tissue expression profiles
of five isoforms of UCPs in normal and diet-induced obese (DIO) rats using real-time polymerase chain reaction (PCR) analysis.
The results clearly show that the tissue-specific expression patterns of individual isoforms between DIO and normal rats are
quite distinct, which suggests a close relationship between the alterations in UCP expression and dietary obesity. |
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