Interstitial cell migration: integrin-dependent and alternative adhesion mechanisms |
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Authors: | Samuel Schmidt Peter Friedl |
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Institution: | 1. Microscopical Imaging of the Cell, Department of Cell Biology (283), Radboud University Nijmegen Medical Centre, P.O. Box?9101, 6500 HB, Nijmegen, The Netherlands 2. Rudolf Virchow Zentrum and Department for Dermatology, University of Würzburg, Josef-Schneider-Strasse 2, 97080, Würzburg, Germany
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Abstract: | Adhesion and migration are integrated cell functions that build, maintain and remodel the multicellular organism. In migrating
cells, integrins are the main transmembrane receptors that provide dynamic interactions between extracellular ligands and
actin cytoskeleton and signalling machineries. In parallel to integrins, other adhesion systems mediate adhesion and cytoskeletal
coupling to the extracellular matrix (ECM). These include multifunctional cell surface receptors (syndecans and CD44) and
discoidin domain receptors, which together coordinate ligand binding with direct or indirect cytoskeletal coupling and intracellular
signalling. We review the way that the different adhesion systems for ECM components impact cell migration in two- and three-dimensional
migration models. We further discuss the hierarchy of these concurrent adhesion systems, their specific tasks in cell migration
and their contribution to migration in three-dimensional multi-ligand tissue environments. |
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