| piRNA生物学起源及功能研究进展 |
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| 引用本文： | 颜愈佳,邹玲.piRNA生物学起源及功能研究进展[J].中国生物工程杂志,2021,41(5):45-50. |
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| 作者姓名： | 颜愈佳 邹玲 |
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| 作者单位： | 四川大学华西口腔医院牙体牙髓病科 口腔疾病研究国家重点实验室 国家口腔疾病临床医学研究中心 成都 610041 |
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| 摘 要： | piRNA属于非编码小RNA的一员,常见于生殖系干细胞中。既往学者们认为它主要在维持干细胞功能、配子的形成以及沉默外来转座子等方面发挥作用。但近来在体细胞系中的发现,使得人们对它的生物起源以及功能行使有了更大的兴趣。就piRNA的发现、结构特征、功能与基因调控等进行了综述。
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| 关 键 词： | piRNA PIWI 表观遗传调控 转录后水平调控 |
| 收稿时间： | 2021-01-07 |
Research Progress on the Biogenesis and Function of piRNAs |
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| YAN Yu-jia,ZOU Ling.Research Progress on the Biogenesis and Function of piRNAs[J].China Biotechnology,2021,41(5):45-50. |
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| Authors: | YAN Yu-jia ZOU Ling |
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| Abstract: | PiRNA is a member of non-coding small RNA, which is commonly detected in germline cells. Previously scholars used to believe that piRNA mainly plays a role in maintaining the function of stem cells,formation of the gametes and silencing foreign transposon genes.But recent discoveries which show the piRNA traces in somatic cells have led to greater interest in its biogenesis and further function. The discovery, structure, function and gene regulation of piRNA were reviewed. |
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