乳杆菌对致病假单胞菌的抑制作用研究进展*

假单胞菌污染事件在临床就医和日常饮食中频发,屡次产生致病、致死等恶劣后果,有效抑制致病假单胞菌并降低其耐药性作为解决该问题的关键手段,是目前的研究重点。相关研究表明益生菌等天然活性成分对假单胞菌产生多方面影响,以应用范围最广的益生菌——乳杆菌为例,综合国内外最新研究进展,论述了乳杆菌对假单胞菌的生物膜结构、生长活性、生物毒性、黏附细胞表面能力及被假单胞菌感染后的小鼠等产生的影响。深入挖掘乳杆菌等益生菌及其代谢产物成分的作用机制,是防治假单胞菌等微生物污染和感染的关键。

Research Progress on the Inhibitory Effect of Lactobacillus on Pathogenic Pseudomonas

Pseudomonas contamination incidents are not seldom encountered in clinical treatment and daily diet, which may result in illness, death and other undesirable consequences. To this end,recent studies focus on the inhibiting of pathogenic Pseudomonas and the reducing of their drug resistance, in which it has been proved that the excruciating characters of Pseudomonas can be improved by natural active ingredients (for example, probiotics). As a kind of widely existing probiotics, Lactobacillus is utilized for the survey. By considering the studies all over the world up to date, effects of Lactobacillus on the biofilm structure, growth activity, ability to adhere to cell surfaces and biological toxicity of Pseudomonas are introduced. Also, the influence of mice infected by Pseudomonas are is demonstrated. Based on the surveys aforementioned, it is significant to find out biological principles of influence on Pseudomonas of Lactobacillus and other probiotics (including their metabolites), which are the key to prevent and control microbial contamination and infection.