Altered expression of genes in adipose tissues associated with reduced fat mass in patients with pancreatic cancer |
| |
| Authors: | Haugen F Labori K J Noreng H J Buanes T Iversen P O Drevon C A |
| |
| Institution: | Department of Nutrition, Institute of Basic Medical Sciences, University of Oslo, Norway. fred.haugen@medisin.uio.no |
| |
| Abstract: | Loss of adipose tissue in patients with pancreatic cancer may involve altered gene expression. Peri-operative mRNA levels of 44 genes were analysed by RT-PCR in intra-abdominal (IAAT) and subcutaneous adipose tissue (SCAT) sampled from pancreatic ductal adenocarcinoma (PDAC) patients undergoing tumour resection (n?=?20), and control patients without cancer (n?=?11). Peri- and post-operative IAAT and SCAT masses were measured by computerized tomography. PDAC patients displayed 2.6- and 1.7-fold higher Zn-α2-glycoprotein (AZGP1) mRNA levels than controls in IAAT and SCAT, respectively (P?
|
| |
| Keywords: | |
| 本文献已被 PubMed 等数据库收录！ |
|
