The Immunopurification of Tetanus Toxoid |
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| Authors: | M. Hughes R. O. Thomson P. Knight J. Stephen |
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| Affiliation: | Department of Bacteriology, Wellcome Research Laboratories, Langley Court, Langley Park, Beckenham BR3 3BS, Kent, England;Department of Microbiology, University of Birmingham, Birmingham, England |
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| Abstract: | S ummary . The isolation of tetanus toxoid by immunosorption chromatography is described. The immunosorbent, a polymerized horse antitoxin, was used repeatedly with little loss in capacity and recoveries of toxoid of > 90% were achieved. In terms of specific antigenic activity, immunopurified tetanus toxoid is purer than that purified by conventional procedures and is at least as immunogenic. |
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