Fluid and solid mechanics in a poroelastic network induced by ultrasound |
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| Authors: | Peng Wang William L. Olbricht |
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| Affiliation: | 1. School of Chemical and Biomolecular Engineering, Cornell University, 120 Olin Hall, Ithaca, NY 14853, USA;2. Department of Biomedical Engineering, Cornell University, Ithaca, NY 14853, USA;1. Department of Obstetrics and Gynecology, Shandong Provincial Hospital Affiliated to Shandong University, Jinan, 250021, Shandong, China;2. Center for Reproductive Medicine, Shandong Provincial Hospital Affiliated to Shandong University, Jinan, China;3. National Research Center for Assisted Reproductive Technology and Reproductive Genetics, China;4. The Key Laboratory for Reproductive Endocrinology of Ministry of Education, China;5. Center for Reproductive Medicine, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, 200030, China;6. Shanghai Key Laboratory for Assisted Reproduction and Reproductive Genetics, Shanghai, China;1. Division of Toxicology, Wageningen University, Tuinlaan 5, 6703 HE Wageningen, The Netherlands;2. Experimental Toxicology and Ecology, BASF SE, Z 470, 67056 Ludwigshafen, Germany;1. School of Engineering and Technology, China University of Geosciences (Beijing), Beijing 100083, China;2. Division of Intelligent and Biomechanical Systems, State Key Laboratory of Tribology, Department of Mechanical Engineering, Tsinghua University, Beijing 100084, China;1. Department of Mechanical Engineering, Pohang University of Science and Technology, Pohang Gyeongbuk 790-784, Republic of Korea;2. Center for Biofluid and Biomimic Research, Pohang University of Science and Technology, Pohang Gyeongbuk 790-784, Republic of Korea;1. UMR Ingénierie Procédés Aliments, AgroParisTech, INRA, Université Paris-Saclay, 91300, Massy, France;2. UMR CNRS 6607, Laboratoire de Thermique et Energie de Nantes, Université de Nantes, 44300, Nantes, France;1. Chemical and Environmental Engineering Department, Federico Santa María Technical University, Av. España 1680, Valparaíso, Chile;2. Centro Regional de Estudios en Alimentos y Salud (CREAS) Conicyt-Regional GORE Valparaíso Project R17A10001, Avenida Universidad 330, Curauma, Valparaíso, Chile |
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| Abstract: | We made a theoretical analysis on the fluid and solid mechanics in a poroelastic medium induced by low-power ultrasound. Using a perturbative approach, we were able to linearize the governing equations and obtain analytical solutions. We found that ultrasound could propagate in the medium as a mechanical wave, but would dissipate due to frictional forces between the fluid and the solid phase. The amplitude of the wave depends on the ultrasonic power input. We applied this model to the problem of drug delivery to soft biological tissues by low-power ultrasound and proposed a mechanism for enhanced drug penetration. We have also found the coexistence of two acoustic waves under certain circumstances and pointed out the importance of very accurate experimental determination of the high-frequency properties of brain tissue. |
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