Synthesis and biological evaluation of N-(aryl)-2-thiophen-2-ylacetamides series as a new class of antitubercular agents |
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| Authors: | Silva Lourenço Maria Cristina Rodrigues Vicente Felipe de Oliveira Henriques Maria das Graças Muller Peixoto Candéa André Luis Borges Gonçalves Raoni Schroeder Nogueira Thais Cristina M de Lima Ferreira Marcelle Nora de Souza Marcus Vinícius |
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| Institution: | aFioCruz-Fundação Oswaldo Cruz, Instituto de Tecnologia em Fármacos-Far Manguinhos, Rua Sizenando Nabuco 100, Manguinhos, 21041-250 Rio de Janeiro, RJ, Brazil;bInstituto de Pesquisas Clínica Evandro Chagas—IPEC, Av. Brasil, 4365 Manguinhos Rio de Janeiro, RJ, Brazil |
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| Abstract: | The present article describes a series of 21 N-(aryl)-2-thiophen-2-ylacetamides, which were synthesized and evaluated for their in vitro antibacterial activity against Mycobacterium tuberculosis, and the activity expressed as the minimum inhibitory concentration (MIC) in μg/mL. The compounds 2, 3, 7, 8, 11, 12, 15, 16, and 20 exhibited activity between 25 and 100 μg/mL and could be a good start point to find new lead compounds in the fight against multidrug resistant tuberculosis. |
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| Keywords: | Thiopheneacetamides Tuberculosis Antimycobacterial activity |
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