A facile one-pot synthesis of 4,5-diaryl-2,2-dimethyl-3(2H)-furanones |
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Authors: | Lee Ki-Wha Choi Young Hoon Joo Yung Hyup Kim Jin Kwan Shin Song Seok Byun Young Joo Kim Yeonjoon Chung Shin |
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Affiliation: | Drug Discovery, Pacific Corporation R&D Center, 314-1 Bora-ri, Kiheung-eup, Yongin-si, 449-729, Kyounggi-do, South Korea. |
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Abstract: | An efficient and practical one-pot synthesis of 4,5-diaryl-2,2-dimethyl-3(2H)-furanones has been achieved from 1,2-diarylethanones and 2-bromoisobutyryl cyanide in the presence of excess base, by employing the 'hard soft acid base' principle. The reaction scope of 2-bromoisobutyryl cyanide could be expanded to prepare a variety of 2,2-dimethyl-3(2H)-furanone derivatives other than 4,5-diaryl-2,2-dimethyl-3(2H)-furanones. |
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