Genetic aspects of quantitative variation in the carbonic anhydrases of the pig-tailed macaque,Macaca nemestrina. I. Response to thyroxine |
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| Authors: | Stephen I. O. Anyaibe Verle E. Headings |
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| Affiliation: | 1. Division of Medical Genetics, Department of Pediatrics and Child Health, Howard University College of Medicine, Washington, D.C.
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| Abstract: | Effects of thyroxine on incorporation of l-serine-C14 into four carbonic anhydrase isozymes (CA II, CA Ia, CA Ib, CA Ic) and hemoglobin were quantified in reticulocytes of Macaca nemestrina in vitro. Response to thyroxine differed significantly between CA Ia and two allelic variants (CA Ib and CA Ic) and the nonallelic isozyme (CA II). The effects of thyroxine on serine incorporation into hemoglobin and three of the carbonic anhydrase isozymes were shown to be nonlinear with thyroxine concentration. |
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