Microarray Based Gene Expression Analysis of Murine Brown and Subcutaneous Adipose Tissue: Significance with Human |
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| Authors: | Ritesh K. Baboota Siddhartha M. Sarma Ravneet K. Boparai Kanthi Kiran Kondepudi Shrikant Mantri Mahendra Bishnoi |
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| Affiliation: | 1National Agri-Food Biotechnology Institute (NABI), SAS Nagar, Punjab, India;2Department of Biochemistry, Panjab University, Chandigarh, India;The Perinatal Institute, Cincinnati Children''s Hospital Medical Center and University of Cincinnati, UNITED STATES |
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| Abstract: | BackgroundTwo types of adipose tissues, white (WAT) and brown (BAT) are found in mammals. Increasingly novel strategies are being proposed for the treatment of obesity and its associated complications by altering amount and/or activity of BAT using mouse models.ConclusionOur study provides evidence for inter species (mouse vs human) differences in differential gene expression between sWAT and BAT. Critical understanding of this data may help in development of novel ways to engineer one form of adipose tissue to another using murine model with focus on human. |
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