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Microarray Based Gene Expression Analysis of Murine Brown and Subcutaneous Adipose Tissue: Significance with Human
Authors:Ritesh K. Baboota  Siddhartha M. Sarma  Ravneet K. Boparai  Kanthi Kiran Kondepudi  Shrikant Mantri  Mahendra Bishnoi
Affiliation:1National Agri-Food Biotechnology Institute (NABI), SAS Nagar, Punjab, India;2Department of Biochemistry, Panjab University, Chandigarh, India;The Perinatal Institute, Cincinnati Children''s Hospital Medical Center and University of Cincinnati, UNITED STATES
Abstract:BackgroundTwo types of adipose tissues, white (WAT) and brown (BAT) are found in mammals. Increasingly novel strategies are being proposed for the treatment of obesity and its associated complications by altering amount and/or activity of BAT using mouse models.ConclusionOur study provides evidence for inter species (mouse vs human) differences in differential gene expression between sWAT and BAT. Critical understanding of this data may help in development of novel ways to engineer one form of adipose tissue to another using murine model with focus on human.
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