Connection between foreign DNA replication and induced expression of the restriction-modification system inStreptomyces aureofaciens |
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Authors: | A Godány J Farka?ovská G Bukovská J Timko |
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Institution: | (1) Institute of Molecular Biology, Slovak Academy of Sciences, 842 51 Bratislava, Slovakia |
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Abstract: | Tetracycline-producing strains ofStreptomyces aureofaciens expressedSauLPI restriction-modification (R-M) system, which recognized specific DNA sequence 5′-GCCGGC-3′ (isoschizomerNaeI). The activation of the second R-M systemSauLPII (5′-GAGCTC-3′, isoschizomer ofXhoI), which was silent during the growth cycle, after a foreign DNA transfer into this strain was observed. This phenomenon
was tentatively explained as a response of the cells against the exogenous DNA entering the cells. The involvement of a SOS-like
response in induction of R-M system genes inS. aureofaciens strains has been considered. |
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