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Epitope spreading to citrullinated antigens in mouse models of autoimmune arthritis and demyelination |
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| Authors: | Brian A Kidd Peggy P Ho Orr Sharpe Xiaoyan Zhao Beren H Tomooka Jennifer L Kanter Lawrence Steinman William H Robinson |
| Affiliation: | (1) Department of Medicine, Division of Immunology and Rheumatology, CCSR 4135, Stanford University School of Medicine, 269 Campus Dr., Stanford, CA, USA;(2) GRECC, Palo Alto VA Health Care System, 3801 Miranda Ave., Palo Alto, CA, USA;(3) University of Washington, 1705 NE Pacific St., Seattle, WA, USA;(4) Department of Neurology and Neurological Sciences, Stanford University School of Medicine, ckman B-002, 279 Campus Dr., Stanford, CA, USA |
| Abstract: | IntroductionAnti-citrullinated protein antibodies have a diagnostic role in rheumatoid arthritis (RA); however, little is known about their origins and contribution to pathogenesis. Citrullination is the post-translational conversion of arginine to citrulline by peptidyl arginine deiminase, and increased citrullination of proteins is observed in the joint tissue in RA and in brain tissue in multiple sclerosis (MS). |
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