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CFTR and Wnt/beta-catenin signaling in lung development |
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| Authors: | J Craig Cohen Janet E Larson Erin Killeen Damon Love Ken-Ichi Takemaru |
| Institution: | (1) The Brady Laboratory, Section of Neonatology, Department of Pediatrics, Stony Brook University, School of Medicine, Stony Brook, New York, USA;(2) Department of Pharmacological Sciences, Stony Brook University, School of Medicine, Stony Brook, New York, USA |
| Abstract: | BackgroundCystic fibrosis transmembrane conductance regulator (CFTR) was shown previously to modify stretch induced differentiation in the lung. The mechanism for CFTR modulation of lung development was examined by in utero gene transfer of either a sense or antisense construct to alter CFTR expression levels. |
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