Chemokines as mediators of tumor angiogenesis and neovascularization |
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| Authors: | Keeley Ellen C Mehrad Borna Strieter Robert M |
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| Affiliation: | aDepartment of Medicine, Divisions of Cardiology, University of Virginia, Charlottesville, VA, USA;bDepartment of Medicine, Pulmonary and Critical Care Medicine, University of Virginia, Charlottesville, VA, USA |
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| Abstract: | Chemokines are a superfamily of structurally homologous heparin-binding proteins that influence tumor growth and metastasis. Several members of the CXC and CC chemokine families are potent inducers of neovascularization, whereas a subset of the CXC chemokines are potent inhibitors. In this paper, we review the current literature regarding the role of chemokines as mediators of tumor angiogenesis and neovascularization. |
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| Keywords: | Chemokines Angiogenesis Cancer |
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