Vascular smooth muscle cell proliferation as a therapeutic target. Part 1: molecular targets and pathways |
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| Authors: | Dongdong Wang Pavel Uhrin Andrei Mocan Birgit Waltenberger Johannes M. Breuss Devesh Tewari Judit Mihaly-Bison Łukasz Huminiecki Rafał R. Starzyński Nikolay T. Tzvetkov Jarosław Horbańczuk Atanas G. Atanasov |
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| Affiliation: | 1. Department of Molecular Biology, Institute of Genetics and Animal Breeding of the Polish Academy of Sciences, ul. Postepu 36A, Jastrz?biec, 05-552 Magdalenka, Poland;2. Department of Pharmacognosy, University of Vienna, Althanstrasse 14, A-1090 Vienna, Austria;3. Institute of Clinical Chemistry, University Hospital Zurich, Wagistrasse 14, 8952 Schlieren, Switzerland;4. Center for Physiology and Pharmacology, Institute of Vascular Biology and Thrombosis Research, Medical University of Vienna, Schwarzspanierstrasse 17, 1090 Vienna, Austria;5. Department of Pharmaceutical Botany, “Iuliu Ha?ieganu” University of Medicine and Pharmacy, Strada Gheorghe Marinescu 23, 400337 Cluj-Napoca, Romania;6. Institute for Life Sciences, University of Agricultural Sciences and Veterinary Medicine of Cluj-Napoca, Calea M?n??tur 3-5, 400372 Cluj-Napoca, Romania;g. Institute of Pharmacy/Pharmacognosy and Center for Molecular Biosciences Innsbruck (CMBI), University of Innsbruck, Innrain 80-82, 6020 Innsbruck, Austria;h. Department of Pharmaceutical Sciences, Faculty of Technology, Kumaun University, Bhimtal, 263136 Nainital, Uttarakhand, India;i. Pharmaceutical Institute, University of Bonn, An der Immenburg 4, 53121 Bonn, Germany;j. NTZ Lab Ltd., Krasno Selo 198, 1618 Sofia, Bulgaria |
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| Abstract: | Cardiovascular diseases are a major cause of human death worldwide. Excessive proliferation of vascular smooth muscle cells contributes to the etiology of such diseases, including atherosclerosis, restenosis, and pulmonary hypertension. The control of vascular cell proliferation is complex and encompasses interactions of many regulatory molecules and signaling pathways. Herein, we recapitulated the importance of signaling cascades relevant for the regulation of vascular cell proliferation. Detailed understanding of the mechanism underlying this process is essential for the identification of new lead compounds (e.g., natural products) for vascular therapies. |
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