Exosome biogenesis,bioactivities and functions as new delivery systems of natural compounds |
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| Authors: | Ammad Ahmad Farooqi Nishil N Desai Muhammad Zahid Qureshi Daniele Rubert Nogueira Librelotto Maria Luisa Gasparri Anupam Bishayee Seyed Mohammad Nabavi Valeria Curti Maria Daglia |
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| Institution: | 1. Laboratory for Translational Oncology and Personalized Medicine, Rashid Latif Medical College, Lahore, Pakistan;2. Department of Pharmaceutical Sciences, College of Pharmacy, Larkin University, Miami, FL, USA;3. Department of Chemistry, Government College University, Lahore, Pakistan;4. Departamento de Farmácia Industrial, Universidade Federal de Santa Maria, Santa Maria, Brazil;5. Department of Obstetrics and Gynecology, University of Bern, Bern, Switzerland;6. Department of Gynecology, Obstetrics and Urology, “Sapienza” University of Rome, Rome, Italy;g. Surgical and Medical Department of Translational Medicine, “Sapienza” University of Rome, Rome, Italy;h. Department of Drug Sciences, Medicinal Chemistry and Pharmaceutical Technology Section, University of Pavia, Italy;i. Applied Biotechnology Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran |
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| Abstract: | A rapidly growing body of experimental evidence has begun to shed light on the wide ranging molecular mechanisms which modulate intra- and inter-cellular communications. A substantial quantity of the available knowledge has only been uncovered in recent years, and we are learning that donor cells release nanovesicles, known as exosomes, which regulate the cellular behavior of recipient cells following uptake. Based on the impressive capacity of exosomes in delivering their “payload”, different therapeutic agents, are currently being tested using this delivery method for more effective therapy. This review summarizes the most recent developments in exosome bioactivities and discusses the biochemical nature of exosomes and their biogenesis. It also summarizes the use of exosomes as delivery vehicles for drugs and natural compounds to the targeted site. |
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| Keywords: | Exosomes Drug delivery Phytochemicals Curcumin |
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