High hydrostatic pressure in cancer immunotherapy and biomedicine |
| |
| Authors: | Irena Adkins Nada Hradilova Ondrej Palata Lenka Sadilkova Lenka Palova-Jelinkova Radek Spisek |
| |
| Institution: | 1. Sotio a.s, Prague, Czech Republic;2. Department of Immunology, 2nd Faculty of Medicine, Charles University, University Hospital Motol, Prague, Czech Republic |
| |
| Abstract: | High hydrostatic pressure (HHP) has been known to affect biological systems for >100?years. In this review, we describe the technology of HHP and its effect macromolecules and physiology of eukaryotic cells. We discuss the use of HHP in cancer immunotherapy to kill tumor cells for generation of whole cell and dendritic cell-based vaccines. We further summarize the current use and perspectives of HHP application in biomedicine, specifically in orthopedic surgery and for the viral, microbial and protozoan inactivation to develop vaccines against infectious diseases. |
| |
| Keywords: | HHP high hydrostatic pressure DC dendritic cells CRT Calreticulin High hydrostatic pressure Cancer Immunotherapy Vaccine Orthopedic surgery Dendritic cell Virus inactivation |
| 本文献已被 ScienceDirect 等数据库收录！ |
