Mitochondrial biogenesis related endurance genotype score and sports performance in athletes |
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| Authors: | Nir Eynon Jonatan R. Ruiz Yoav Meckel María Morán Alejandro Lucia |
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| Affiliation: | 1. Department of Nanobiomedical Science, College of Natural Science, Dankook University, Cheonan, South Korea;2. Environmental Health Center, Dankook Medical Hospital, Cheonan, South Korea;3. Department of Psychology, College of Public Welfare, Dankook University, Cheonan, South Korea;4. Department of Preventive Medicine, College of Medicine, Dankook University, Cheonan, South Korea |
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| Abstract: | We determined the probability of individuals having the ‘optimal’ mitochondrial biogenesis related endurance polygenic profile, and compared the endurance polygenic profile of Israeli (Caucasian) endurance athletes (n = 74), power athletes (n = 81), and non-athletes (n = 240). We computed a mitochondrial biogenesis related ‘endurance genotype score’ (EGS, scoring from 0 to 100) from the accumulated combination of six polymorphisms in the PPARGC1A-NRF-TFAM pathway. Some of the variant alleles of the polymorphisms studied were so infrequent, that the probability of possessing an ‘optimal’ EGS (= 100) was 0% in the entire study population. However, the EGS was significantly higher (P < 0.001) in endurance athletes (38.9 ± 17.1) compared with controls (30.6 ± 12.4) or power athletes (29.0 ± 11.2). In summary, although the probability of an individual possessing a theoretically ‘optimal’ genetic background for endurance sports is very low, in general endurance athletes have a polygenic profile that is more suitable for mitochondrial biogenesis. |
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