Impact of KIR/HLA ligand combinations on immune responses in malignant melanoma |
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Authors: | Elissaveta Naumova Anastassia Mihaylova Milena Ivanova Snejina Mihailova |
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Institution: | Central Laboratory of Clinical Immunology, University Hospital Alexandrovska, 1431, Sofia, Bulgaria. immun@alexandrovska-hospital.bg |
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Abstract: | Tumor growth and dissemination depend partly on the reactivity of natural killer (NK) cells and T cells expressing NK-associated receptors. Their effector functions are regulated by an array of activating and inhibitory cell surface receptors with MHC class I ligand specificity, such as the killer immunoglobulin-like receptors (KIRs). Given the extensive genomic diversity of KIRs and their HLA ligands, it is reasonable to speculate that HLA, KIR gene variations and specific KIR-ligand combinations will have an impact on disease susceptibility and/or progression. Here, we discuss how KIR genotypes and KIR/HLA immunogenetic profiles may be involved in tumorigenesis, especially in malignant melanoma (MM). A hypothetical model of the impact of KIR/ligand combinations on immune responses in MM is proposed. |
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Keywords: | KIR HLA Polymorphism Malignant melanoma |
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