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Constrained models of evolution lead to improved prediction of functional linkage from correlated gain and loss of genes |
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| Authors: | Barker Daniel Meade Andrew Pagel Mark |
| Institution: | Sir Harold Mitchell Building, School of Biology, University of St Andrews St Andrews, Fife, KY16 9TH, UK. |
| Abstract: | |
| Keywords: | Pellegrini et al" target="_blank">for the proteins (Pellegrini et al 1999) von Mering et al" target="_blank">shared subcellular compartment or functional category (von Mering et al 2002 Lu et al" target="_blank">Lu et al 2003) von Mering et al" target="_blank">or shared complex membership (von Mering et al 2002 Barker and Pagel" target="_blank">Barker and Pagel 2005) These methods of validation are necessarilycorrelated with each other For a simple conservative assessmentof prediction quality we here use data on complex membership |
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