Protective effect of melatonin against propoxur-induced oxidative stress and suppression of humoral immune response in rats |
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| Authors: | Suke Sanvidhan G Kumar Achint Ahmed Rafat S Chakraborti Ayanabha Tripathi A K Mediratta P K Banerjee B D |
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| Affiliation: | Environmental Biochemistry Laboratory, Department of Biochemistry, University College of Medical Sciences and GTB Hospital, (University of Delhi), India. |
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| Abstract: | Effect of melatonin in attenuation of propoxur induced oxidative stress and suppression of humoral immune response was studied in rats. Oral administration of propoxur (10 mg/kg) increased lipid peroxidation in serum after 28 days treatment. Superoxide dismutase, catalase and glutathione were also altered following propoxur exposure. In addition propoxur exposure markedly suppressed humoral immune response as assessed by antibody titre and plaque forming cell assay. Simultaneous treatment with melatonin (5 mg/kg, ip) markedly attenuated the effect of propoxur on (a) lipid peroxidation, (b) oxidative stress parameters and (c) immunotoxicity. Results have been discussed in the light of possible immunopotentiating and antioxidant effects of melatonin to understand the influence of oxidative stress on propoxur induced immunomodulation. |
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