Prediction ofcis/transisomerization in proteins using PSI-BLAST profiles and secondary structure information |
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| Authors: | Jiangning Song Kevin Burrage Zheng Yuan Thomas Huber |
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| Institution: | (1) Advanced Computational Modelling Centre The University of Queensland, 4072 Brisbane Qld, Australia;(2) Institute for Molecular Bioscience and ARC Centre in Bioinformatics The University of Queensland, 4072 Brisbane Qld, Australia |
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| Abstract: | Background The majority of peptide bonds in proteins are found to occur in thetransconformation. However, for proline residues, a considerable fraction of Prolyl peptide bonds adopt thecisform. Prolinecis/transisomerization is known to play a critical role in protein folding, splicing, cell signaling and transmembrane active transport.
Accurate prediction of prolinecis/transisomerization in proteins would have many important applications towards the understanding of protein structure and function. |
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