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Text mining of full-text journal articles combined with gene expression analysis reveals a relationship between sphingosine-1-phosphate and invasiveness of a glioblastoma cell line |
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| Authors: | Jeyakumar Natarajan Daniel Berrar Werner Dubitzky Catherine Hack Yonghong Zhang Catherine DeSesa James R Van Brocklyn Eric G Bremer |
| Institution: | 1. School of Biomedical Sciences, University of Ulster at Coleraine, Cromore Road, Northern Ireland, UK 2. Brain Tumor Research Program, Children's Memorial Research Center, 2300 Children's Plaza, M/C 226, Chicago, IL, 60614, USA 4. Windber Research Institute, Windber, PA, USA 3. Division of Neuropathology, Department of Pathology, The Ohio State University, 4164 Graves Hall, 333 W. 10th Ave., Columbus, Ohio, 43210, USA |
| Abstract: | BackgroundSphingosine 1-phosphate (S1P), a lysophospholipid, is involved in various cellular processes such as migration, proliferation, and survival. To date, the impact of S1P on human glioblastoma is not fully understood. Particularly, the concerted role played by matrix metalloproteinases (MMP) and S1P in aggressive tumor behavior and angiogenesis remains to be elucidated. |
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