Stereoselective behavior of a novel biodegradable racemic ketoprofen injectable implant in rats |
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Authors: | Wang Sheng-Hao Yin Li-Na Liang Ze-Hua Lu Si-Jie Zeng Su |
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Institution: | College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, Zhejiang 310031, People's Republic of China. |
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Abstract: | The stereoselectivity of release of ketoprofen (KET) enantiomers from a biodegradable injectable implant containing racemic KET (rac-KET) was investigated in vivo. A pre-column chiral derivatization RP-HPLC method was employed to assay diastereoisomeric derivatives of R- and S-KET. The rac-KET injectable implant, once injected subcutaneously in rats, produced long-lasting plasma levels of S-KET, which were always greater than those of R-KET. The difference in enantiomer concentration was to be related to stereoselective release, due to stereoselective interaction between D,L-PLG in the implant and KET enantiomers, as well as the chiral inversion of KET in vivo. The rac-KET injectable implant provided the sustained release of S-KET with effective plasma levels maintained for about 8 wk after a single injection. |
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Keywords: | stereoselectivity ketoprofen enantiomer biodegradable injectable implant pre‐column chiral derivatization RP‐HPLC |
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