The comparison of gastroprotective properties of Semax and its metabolites |
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| Authors: | Z V Bakaeva K E Baglikova P A Klimova L A Andreeva G E Samonina |
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| Institution: | 1.Department of Human and Animal Physiology, Biological Faculty,Moscow State University,Moscow,Russia;2.Kalmyk State University,Elista,Russia;3.Institute of Molecular Genetics,Russian Academy of Sciences,Moscow,Russia |
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| Abstract: | Semax (MEHFPGP) was shown to increase gastric mucosal homeostasis to the action of such ulcerogenic factors as ethanol and
stress. In the case of the stress model of ulcer formation, Semax and its two metabolites—HFPGP and FPGP—at the wide range
of doses (0.06–3.7 μmol/kg) have demonstrated protective antiulcerogenic properties. In the case of ethanol model of ulcer
formation, only Semax in two used doses (0.06 and 0.37 μmol/kg) reported reliable protective antiulcerogenic property. It
was supposed that Semax’s gastroprotective activity directed to peripheral mechanisms of ulcerogenesis did not depend on its
metabolites’ activities. On the contrary, Semax’s gastroprotective activity directed to the central mechanisms of ulcerogenesis
might be also caused by gastroprotective activities of HFPGP and FPGP metabolites. |
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