Electrochemical Characteristics of Nitro-Heterocyclic Compounds of Biological Interest. II. Nitrosochloramphenicol |
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Authors: | J H Tocher R C Knight D I Edwards |
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Institution: |
a Chemotherapy Research Unit, North East London Polytechnic, London |
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Abstract: | The electrochemical Characteristics of nitrosochloramphenicol have been studied in aqueous buffer systems (pH 7.1) using direct current (d.c.) and differential pulse polarography. cyclic voltammetry and coulometric techniques. Up to 4 charge-transfer steps can be identified. The first reduction step is reversible both chemically and electrochemically. the charge-transfer product showing no tendency to undergo further reaction on the electrochemical time-scale. In contrast, the second reduction step is irreversible, with the product undergoing a fast following reaction to yield a redox-active species which was detected by cyclic voltammetry. From the data and by comparison with related systems. two reduction mechanisms are possible and are discussed. |
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Keywords: | Nitrosochloramphenicol free radicals reduction cyclic voltammetry |
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