H-Y transplantation antigen in human XO females |
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Authors: | Ulf H. Wiberg |
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Affiliation: | (1) Institut für Humangenetik und Anthropologie, Albertstraße 11, D-7800 Freiburg i.B., Federal Republic of Germany;(2) Genetiska Institutionen, Lunds Universitet, Sölvegatan 29, S-223 62 Lund, Sweden |
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Abstract: | Summary When sensitized with human cultured fibroblasts of the XY and XO, but not XX, sex chromosomal types C57BL/6 female mice reject syngeneic male grafts accelerated (second set graft reaction). These findings demonstrate that the antigenic determinants of H-Y antigen of man and mouse are homologous and that XO females (at least those tested) carry the H-Y transplantation antigen. The results are discussed in the light of the question of differences between the H-Y antigen as defined by grafting and serology and the chromosomal localization of the H-Y structural gene(s). |
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