The role of Sirt1: At the crossroad between promotion of longevity and protection against Alzheimer's disease neuropathology |
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| Authors: | Jun Wang Hayley Fivecoat Lap Ho Yong Pan Emi Ling Giulio Maria Pasinetti |
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| Institution: | 1. Center of Excellence for Novel Approaches to Neurodiagnostics and Neurotherapeutics, Brain Institute, Center of Excellence for Research in Complementary and Alternative Medicine in Alzheimer''s Disease, Department of Neurology, Mount Sinai School of Medicine, 1 Gustave L. Levy Place, Box 1137, New York, NY 10029, USA;2. Biomedical Research and Training Program, Geriatric Research, Education and Clinical Center (GRECC), James J. Peters Veterans Affairs Medical Center, 130 West Kingsbridge Road, Bronx, NY 10468, USA |
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| Abstract: | Sirt1, a mammalian member of the sirtuin gene family, holds great potential for promoting longevity, preventing against disease and increasing cell survival. For example, studies suggest that the beneficial impact of caloric restriction in promoting longevity and cellular function may be mediated, in part, by Sirt1 through mechanisms involving PGC-1α, which plays important role in the regulation of cellular metabolism and inflammatory and antioxidant responses. Sirt1 may also interfere with mechanisms implicated in pathological disorders. We will present recent evidence indicating that Sirt1 may protect against Alzheimer's disease by interfering with the generation of β-amyloid peptides. We will discuss Sirt1 as a potential novel target, in addition to the development of Sirt1 activators for the prevention and treatment of Alzheimer's disease. |
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| Keywords: | Sirtuins Caloric restriction Neurodegeneration Alzheimer's disease Dementia |
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