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Bioanalytics and pharmacokinetics of the nociceptin/orphanin FQ peptide receptor agonist RO0646198 in Wistar rats and Cynomolgus monkeys |
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| Authors: | Katja Heinig Nicole KratochwilFranz Bucheli Anita Thomae |
| Institution: | F. Hoffmann-La Roche Ltd., Pharma Research, Non-clinical Safety, CH-4070 Basel, Switzerland |
| Abstract: | |
| Keywords: | RO0646198 Ro 64-6198 NOP receptor agonist Pharmacokinetics Cynomolgus monkeys Liquid chromatography tandem mass spectrometry On-line solid-phase extraction Animal plasma Matrix effect |
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